ペリオスチン

POSTN
識別子
記号	POSTN, OSF-2, OSF2, PDLPN, periostin
外部ID	OMIM: 608777 MGI: 1926321 HomoloGene: 4730 GeneCards: POSTN
遺伝子の位置 (ヒト)
染色体	13番染色体 (ヒト)
終点	37,598,844 bp
遺伝子の位置 (マウス)
染色体	3番染色体 (マウス)
終点	54,298,458 bp
RNA発現パターン
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• 金属イオン結合; • heparin binding; • 血漿タンパク結合; • extracellular matrix structural constituent; • cell adhesion molecule binding;
細胞の構成要素	• 細胞外領域; • 細胞質; • trans-Golgi network; • ゴルジ体; • 細胞外マトリックス; • 神経筋接合; • 細胞外空間; • collagen-containing extracellular matrix;
生物学的プロセス	• negative regulation of substrate adhesion-dependent cell spreading; • regulation of Notch signaling pathway; • 低酸素症への反応; • response to mechanical stimulus; • neuron projection extension; • 傷の治癒; • regulation of systemic arterial blood pressure; • 骨格系発生; • エストラジオールへの反応; • cellular response to fibroblast growth factor stimulus; • bone regeneration; • 組織の発生; • positive regulation of smooth muscle cell migration; • cellular response to transforming growth factor beta stimulus; • negative regulation of cell-matrix adhesion; • response to muscle activity; • 細胞接着; • cellular response to tumor necrosis factor; • cellular response to vitamin K; • extracellular matrix organization;
	出典:Amigo / QuickGO
オルソログ
	10631
	50706
	ENSG00000133110
	ENSMUSG00000027750
	Q15063,A0A024RDS2
	Q62009
NM_001135934; NM_001135935; NM_001135936; NM_001286665; NM_001286666;
	NM_001286667; NM_006475; NM_001330517
NM_001198765; NM_001198766; NM_015784; NM_001313898; NM_001313899;
	NM_001368678
NP_001129406; NP_001129407; NP_001129408; NP_001273594; NP_001273595;
	NP_001273596; NP_001317446; NP_006466; NP_006466.2
NP_001185694; NP_001185695; NP_001300827; NP_001300828; NP_056599;
	NP_001355607
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

ペリオスチン (periostin) は、ヒトのPOSTN遺伝子にコードされたタンパク質である^[5]^[6]。ペリオスチンはαVβ3（英語版）およびαVβ5（英語版）インテグリンのリガンドとして機能し、上皮細胞の接着および遊走を支える^[7]。

臨床的重要性[編集]

喘息[編集]

ペリオスチンは喘息と関連している。これは、喘息の試験薬であるレブリキズマブ (lebrikizumab) に利用されている^[8]。

癌[編集]

ペリオスチンの過剰発現は様々な種類の癌で報告されており、腫瘍細胞の環境で最も頻繁に見られる^[7]^[9]。最近研究では、ペリオスチンは正常組織や原発腫瘍間質中の線維芽細胞によって発現される細胞外マトリックスの構成要素であることが明らかにされている。転移性コロニー形成は浸潤性がん細胞によるストロマ中のペリオスチンの誘導が必要である。ペリオスチンの産生はTGF-β2あるいはTGF-β3によって肺線維芽細胞において上方制御される。TGF-β3は浸潤性がん幹細胞によって分泌される（MMTV-PyMTマウス乳癌モデル）^[10]。

様々ながん細胞株におけるペリオスチンの発現^[11]
細胞株	起源	POSTN/ACTB¹
U2OS	骨肉腫	3.5±1.7
LB96	ユーイング肉腫	0
LB23-1	横紋筋肉腫	0.1±0.1
HeLa	子宮頸癌	3.0±0.4
PA-1	卵巣奇形腫	1.4±0.1
LB37-1	NSCLC	2.8±0.6
LB85	SCLC	3.4±0.2
LB92	SCLC	0.6±0.2
LB1047	腎細胞癌	0.8±0.2
BB64	腎細胞癌	0.08±0.01
LB108	結腸直腸癌	0
MCF7	乳癌	0
Hs578T	乳癌	3693±86
Panc-1	膵癌	0
Capan-1	膵癌	0
Huh-7	肝細胞癌	0.3±0.07
LB831	膀胱癌	1748±74
MZGC3	胃癌	0
A172	膠芽腫	45±4
MZ2	メラノーマ	2.3±0.7
LB39	メラノーマ	0.5±0.03
LB2586-7	メラノーマ	3.4±0.3
LB2201-3	メラノーマ	4.2±0.4
A375	メラノーマ	4.7±1.2

¹ (cDNA POSTN/cDNA ACTB) × 10⁴

脚注[編集]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000133110 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027750 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ Takeshita S, Kikuno R, Tezuka K, Amann E (Sep 1993). “Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I”. Biochem J. 294 ( Pt 1): 271–8. PMC 1134594. PMID 8363580.
^ “Entrez Gene: POSTN periostin, osteoblast specific factor”. 2012年6月12日閲覧。
^ ^a ^b Gillan L, Matei D, Fishman DA, Gerbin CS, Karlan BY, Chang DD (Sep 2002). “Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility”. Cancer Res. 62 (18): 5358–64. PMID 12235007.
^ Kraft M (2011). “Asthma phenotypes and interleukin-13--moving closer to personalized medicine”. N. Engl. J. Med. 365 (12): 1141-1144. PMID 21879891.
^ Contié S, Voorzanger-Rousselot N, Litvin J, et al. (2011). “Increased expression and serum levels of the stromal cell-secreted protein periostin in breast cancer bone metastases.”. Int. J. Cancer 128 (2): 352–60. doi:10.1002/ijc.25591. PMID 20715172.
^ Malanchi I, Santamaria-Martínez A, Susanto E, Peng H, Lehr HA, Delaloye JF, Huelsken J (2011). “Interactions between cancer stem cells and their niche govern metastatic colonization”. Nature 481 (7379): 85-89. doi:10.1038/nature10694. PMID 22158103.
^ Tilman G, Mattiussi M, Brasseur F, van Baren N, Decottignies A. (2007). “Human periostin gene expression in normal tissues, tumors and melanoma: evidences for periostin production by both stromal and melanoma cells.”. Molecular Cancer 6 (80). doi:10.1186/1476-4598-6-80. PMID 18086302.

推薦文献[編集]

Sasaki H, Dai M, Auclair D, et al. (2001). “Serum level of the periostin, a homologue of an insect cell adhesion molecule, as a prognostic marker in nonsmall cell lung carcinomas.”. Cancer 92 (4): 843–8. doi:10.1002/1097-0142(20010815)92:4<843::AID-CNCR1391>3.0.CO;2-P. PMID 11550156.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Dunham A, Matthews LH, Burton J, et al. (2004). “The DNA sequence and analysis of human chromosome 13.”. Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
Shao R, Bao S, Bai X, et al. (2004). “Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression.”. Mol. Cell. Biol. 24 (9): 3992–4003. doi:10.1128/MCB.24.9.3992-4003.2004. PMC 387763. PMID 15082792.
Bao S, Ouyang G, Bai X, et al. (2004). “Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway.”. Cancer Cell 5 (4): 329–39. doi:10.1016/S1535-6108(04)00081-9. PMID 15093540.
Kim CJ, Yoshioka N, Tambe Y, et al. (2005). “Periostin is down-regulated in high grade human bladder cancers and suppresses in vitro cell invasiveness and in vivo metastasis of cancer cells.”. Int. J. Cancer 117 (1): 51–8. doi:10.1002/ijc.21120. PMID 15880581.
Chang Y, Lee TC, Li JC, et al. (2005). “Differential expression of osteoblast-specific factor 2 and polymeric immunoglobulin receptor genes in nasopharyngeal carcinoma.”. Head Neck 27 (10): 873–82. doi:10.1002/hed.20253. PMID 16136586.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). “Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.”. J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
Yan W, Shao R (2006). “Transduction of a mesenchyme-specific gene periostin into 293T cells induces cell invasive activity through epithelial-mesenchymal transformation.”. J. Biol. Chem. 281 (28): 19700–8. doi:10.1074/jbc.M601856200. PMID 16702213.
Försti A, Jin Q, Altieri A, et al. (2007). “Polymorphisms in the KDR and POSTN genes: association with breast cancer susceptibility and prognosis.”. Breast Cancer Res. Treat. 101 (1): 83–93. doi:10.1007/s10549-006-9265-1. PMID 16807673.
Grigoriadis A, Mackay A, Reis-Filho JS, et al. (2007). “Establishment of the epithelial-specific transcriptome of normal and malignant human breast cells based on MPSS and array expression data.”. Breast Cancer Res. 8 (5): R56. doi:10.1186/bcr1604. PMC 1779497. PMID 17014703.
Baril P, Gangeswaran R, Mahon PC, et al. (2007). “Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta4 integrin and the PI3k pathway.”. Oncogene 26 (14): 2082–94. doi:10.1038/sj.onc.1210009. PMID 17043657.
Siriwardena BS, Kudo Y, Ogawa I, et al. (2007). “Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer.”. Br. J. Cancer 95 (10): 1396–403. doi:10.1038/sj.bjc.6603431. PMC 2360586. PMID 17060937.
Li JS, Sun GW, Wei XY, Tang WH (2007). “Expression of periostin and its clinicopathological relevance in gastric cancer.”. World J. Gastroenterol. 13 (39): 5261–6. PMID 17876898.
Contié S, Voorzanger-Rousselot N, Litvin J, et al. (2010). “Development of a new ELISA for serum periostin: evaluation of growth-related changes and bisphosphonate treatment in mice.”. Calcif. Tissue Int. 87 (4): 341–50. doi:10.1007/s00223-010-9391-y. PMID 20567965.
Kashyap MK,” et al. (2010). “Overexpression of Periostin and Lumican in Esophageal Squamous Cell Carcinoma.”. Cancers. 2 (1): 133–142. doi:10.3390/cancers2010133.

この項目は、生物学に関連した書きかけの項目です。この項目を加筆・訂正などしてくださる協力者を求めています（プロジェクト:生命科学／Portal:生物学）。

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000133110 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027750 - Ensembl, May 2017

[3] Human PubMed Reference:

[4] Mouse PubMed Reference:

[pmid8363580-5] Takeshita S, Kikuno R, Tezuka K, Amann E (Sep 1993). “Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I”. Biochem J. 294 ( Pt 1): 271–8. PMC 1134594. PMID 8363580.

[entrez-6] “Entrez Gene: POSTN periostin, osteoblast specific factor”. 2012年6月12日閲覧。

[pmid12235007-7] Gillan L, Matei D, Fishman DA, Gerbin CS, Karlan BY, Chang DD (Sep 2002). “Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility”. Cancer Res. 62 (18): 5358–64. PMID 12235007.

[8] Kraft M (2011). “Asthma phenotypes and interleukin-13--moving closer to personalized medicine”. N. Engl. J. Med. 365 (12): 1141-1144. PMID 21879891.

[pmid20715172-9] Contié S, Voorzanger-Rousselot N, Litvin J, et al. (2011). “Increased expression and serum levels of the stromal cell-secreted protein periostin in breast cancer bone metastases.”. Int. J. Cancer 128 (2): 352–60. doi:10.1002/ijc.25591. PMID 20715172.

[pmid22158103-10] Malanchi I, Santamaria-Martínez A, Susanto E, Peng H, Lehr HA, Delaloye JF, Huelsken J (2011). “Interactions between cancer stem cells and their niche govern metastatic colonization”. Nature 481 (7379): 85-89. doi:10.1038/nature10694. PMID 22158103.

[pmid18086302-11] Tilman G, Mattiussi M, Brasseur F, van Baren N, Decottignies A. (2007). “Human periostin gene expression in normal tissues, tumors and melanoma: evidences for periostin production by both stromal and melanoma cells.”. Molecular Cancer 6 (80). doi:10.1186/1476-4598-6-80. PMID 18086302.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]